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They are used for several medical reasons (treating type 2 diabetes, reducing risk of heart-related death in certain patients, and preventing the progression of kidney disease in high-risk patients), but they have gained their fame for their effectiveness as a weight loss drug

doi: 10.1007/s12672-025-02469-4 137 MengJGuoFXuHLiangWWangCYangX-D

More specifically, GLP-1R expression has been identified in several hypothalamic and basal forebrain regions, including the paraventricular nucleus, supraoptic nucleus, infundibular nucleus/arcuate nucleus, lateral hypothalamic area, and nuclei of the basal forebrain, where they exhibit relatively well-defined regional expression patterns (43, 44)

Placebo had no effect