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Elevated renal iron levels promote ALOX activation and oxidative stress

Berberine has been extensively documented to lower circulating levels of triglycerides and low-density lipoprotein (LDL) cholesterol

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However, at high concentrations, when RNS levels exceed the capability of its detoxification in the biological system, serious damage to cells may occur [147, 148] due to inhibition of mitochondrial respiratory function by competing with O 2 for interaction with cytochrome oxidase [149] and via nitrative/nitrosative stress [150, 151]