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Improvement in verbal communication, as measured by a ability-appropriate standardized instrument, was significantly greater in participants receiving folinic acid as compared with those receiving placebo, resulting in an effect of 5.7 (1.0,10.4) standardized points with a medium-to-large effect size (Cohens d =0.70)

Botox is a safe treatment approved by the FDA, as long as it is administered by an injector who has sufficient experience and the expertise to achieve good results by customizing the amount and area of treatment for specific patients

Ecotox 18:385402 Hahn ME, Hestermann EV (2008) Receptor-mediated mechanisms of toxicity

doi: 10.1007/978-1-4684-5826-8_11