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During long term human fasting, the acetoacetate/beta-hydroxybutyrate in venous blood exiting muscle and brain was slightly more reduced than the acetoacetate/beta-hydroxybutyrate in the arterial blood entering these tissues with a roughly 3-fold larger reductive shift in muscle compared to brain, while in the fasted state the acetoacetate/beta-hydroxybutyrate in blood exiting the splanchnic bed and kidney was slightly more oxidized than that entering (Aoki et al., 1975

As early as the 1980s, Ames et al

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