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The FDA has only approved six weight loss drugs, including: Bupropion-naltrexone (Contrave) Liraglutide (Saxenda) Orlistat (Xenical, Alli) Phentermine-topiramate (Qsymia) Semaglutide (Wegovy) Setmelanotide (Imcivree) Currently, the choice of weight loss drugs remains very limited and is divided into two main categories: pancreatic lipase inhibitors and appetite suppressants that act on the central nervous system