and US National Institutes of Health grant GM55090 to G.G
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It is found in virtually every cell of the body and plays a critical role in protein synthesis, synthesis and repair of DNA, enzyme function, transport, and cell maturation
Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake