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Depending on the dose, a fraction of APAP is converted into a highly reactive toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), by several P450 cytochromes [34]

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Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism editorial team

We will highlight why a personalized, medically supervised approach is not just beneficial but essential when considering such potent medications