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381 Nonetheless, AT-101 and its derivative FX-11, galloflavin, and N-hydroxyindole-based compounds are promising cell-active LDHA inhibitors, which pharmaceutic effect hasnt been applied in clinical practice

PMCID: PMC9204244

In addition to the hot flashes and night sweats typical of women going through menopause, perimenopausal or menopausal women who may also have a growth hormone deficiency may experience: Insomnia Dryness and thinning of the skin and particularly of the vaginal area Weight gain, particularly belly fat Lack of energy Lack of ability to build muscle Weakened immune response Diminished sex drive and loss of sensitivity to stimulation Hair Loss Anxiety Forgetfulness that may include an increase of Alzheimers disease Depression and other mood changes Symptoms also include the potential loss of bone density and increased risk of heart disease

Funding This work was supported by National Natural Science Foundation of China, China, 81871070