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Keywords: peptides, intranasal delivery, blood-brain barrier (BBB), nebulization, central nervous system (CNS), dry powders, nasal devices 1

Cell migration: In vitro studies have observed TB-500 influencing the migration of keratinocytes, endothelial cells, and fibroblasts in wound models Integrin-linked kinase (ILK) activation: Preclinical data suggest Thymosin Beta-4 activates ILK, which may play a role in cell survival signaling in experimental cardiac models Angiogenic signaling: TB-500 has been observed to stimulate endothelial cell migration and tube formation in in vitro angiogenesis assays

Administration: Subcutaneous or intramuscular injectionis the most common method of administration

The mechanism is attributed to the drug class