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In aged WT versus Mda5 -/- regions we found CTCF (CCCTC-binding factor, 1e-911), ETV2 (Ets variant 2, 1e-248), ERG (ETS transcription factor ERG, 1e-232), IRF3 (1e-21), PU1 (1e-133), JUN-AP1(1e-72) in the reduced regions and CTCF (1e-139), ETV2 (1e-69), ETS1 (1e-55), PU1 (1-36), RUNX (1e-31), IRF3 (1e-05) in the induced regions (Fig

At a 25mg/mL concentration

Interestingly, 78c showed no activity against ADP-ribosyl cyclase at concentrations up to 50 nM, while it exhibited no modulatory effects on CD157, suggesting its specificity toward CD38 139

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