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Multiple technological generationsincluding enteric coatings, protease inhibitors, permeation enhancers, lipid-based systems, polymeric nanoparticles, and mucoadhesive formulationshave been developed to address gastrointestinal degradation and epithelial impermeability, yet none have reliably produced predictable systemic exposure suitable for regulatory approval ( The recent approval of oral semaglutide represents the first unequivocal demonstration that a systemically acting peptide can be administered orally at a commercial scale with reproducible clinical benefit ( Historically, nearly every major therapeutic peptide class has been evaluated for oral delivery

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