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GLP-1RAs and cardiovascular-renal outcomes in type 2 diabetes systematic review (2021) highlights significant reductions in cardiovascular events, kidney disease progression, and mortality among GLP-1 users

While these medications can be highly effective for managing conditions like MASLD, diabetes, and metabolic conditions associated with being in a larger body, they are not without risks

"For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM , that explain poor responders to their medications." "There are a whole class of medications that are insulin sensitizers, so perhaps we can develop medications that will allow people to be sensitized to GLP-1s or find formulations of GLP-1, like the longer-acting versions, that avoid the GLP-1 resistance." The research has been published in Genome Medicine .

It's a clever and effective way to lower blood sugar levels in people with type 2 diabetes