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3 5 Whether it maintains a clinically meaningful gastric-emptying delay across months of once-weekly dosing is unproven, and there is a credible mechanistic reason drawn from the broader behavior of long-acting gut-hormone agonists to suspect the effect may attenuate

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IVD degeneration impairs the function of the spinal unit (IVD, EPs, ligaments, facet joints and vertebral body), causing secondary osteoarthritic changes, bone sclerosis/spondylosis, and neurological signs and deficits due to spinal cord or nerve root compression [10]

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