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This flow of electrons is coupled to the pumping of protons by complexes I, III, and IV across the inner membrane and into the inner mitochondrial membrane space, generating a proton gradient

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However, only mixed forms have been studied for efficacy and side-effects in clinical trials and are generally much less expensive than R-isomer-only products (see What to Consider When Buying)

Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum