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The 3-5x difference in weight loss comes from: Bioavailability Gap: Less than 1% of oral semaglutide reaches your bloodstream versus nearly 100% of injectable forms

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It's a substance called a hydrogel that's made up of cellulose and citric acid

This conversation should cover: The medical necessity of both treatments The expected duration of prednisolone therapy (short-term versus long-term) Individual risk factors, particularly regarding diabetes or prediabetes Realistic expectations about weight loss outcomes whilst on corticosteroids Monitoring requirements for blood glucose and other metabolic parameters The decision to use both medications should be individualised , weighing the clinical benefits of each treatment against potential complications