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Conversely, the reduction in VAT, although documented at both T3 and T6 compared with T0, did not reach statistical significance (see Table 4 and Figure 5 ) Most importantly, the significant weight loss in patients did not lead to a simultaneous decrease in Fat-Free Mass (FFM) and indexed FFM (FFMI) ( Table 4 )

A recent meta-analysis conducted by Patel et al

Reporting summary Further information on experimental design is available in the Nature Research Reporting Summary linked to this article

[9] [10] If nausea becomes severe or persistent, patients should contact their healthcare provider, as dose adjustment may be necessary