observed that the composition of intestinal microbiota in HT patients were significantly different from the composition of intestinal microbiota in the healthy people: the relative abundance of Blautia, Roseburia, Ruminococcus_torques_ group, Romboutsia , Dorea , Fusicatenibacter and Eubacterium_ hallii_ group genera increased, while the relative abundance of Fecalibacterium , Bacteroides , Prevotella_9 and Lachnoclostridiuum genera decreased [35]
Dry, sealed and stored at room temperature, unless otherwise advised on the label
Christen and colleagues found that daily supplementation with 2.5 mg of folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12 for seven years reduced homocysteine levels by 18% in 300 women with three or more risk factors for coronary heart disease but did not affect other cardiovascular inflammatory biomarkers.24 Another study by Kataria and colleagues demonstrated that daily supplementation of 2 mg of folic acid, 25 mg of vitamin B6, and 0.5 mg of vitamin B12 resulted in an 11% reduction in risk of vascular death among 8,513 stroke patients but had no effect on cardiovascular risk.25 In addition, treatment for four weeks with oral doses of 1.8 g/day of N-acetylcysteine, a precursor to the antioxidant glutathione, has been found to lower blood homocysteine levels by reducing cellular oxidation, but has not consistently reduced the risk of cardiac events in cardiovascular patients.26,27 The reasons for the lack of protective effects of folic acid, vitamin B6, and vitamin B12 on inflammatory biomarkers and risk of CVD are unclear
Annals study summary Because this was an observational analysis, it demonstrates an association rather than proving that GLP-1 drugs caused the damage
