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In addition, multiple studies have shown the integrity of the ECM and islet microenvironment is connected to the T1D pathogenesis by promoting cell survival and blocking T cell infiltration into islet tissue ( CVB-associated T1D may also be caused by the viral-associated effects on central tolerance

Glutathione reductase (GR) is a NADPH-dependent oxidoreductase which catalyzes the conversion of oxidized glutathione (GSSG) to reduced glutathione (GSH)

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