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Description

Hypoglycaemia (low blood sugar levels) GLP-1 RAs are glucose-dependent stimulators of insulin, meaning they shouldnt cause dangerous hypoglycemia on their own in a healthy person (unlike taking insulin)

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Yet GLP-1R knockdown in Sim1 neurons did result in a significant reduction in energy expenditure, in contrary to results from whole-body or hypothalamic GLP-1R knockout models

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10.1038/nn.4011 [DOI] [PMC free article] [PubMed] [Google Scholar] Gautron, L

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