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In addition to Complex I inhibition in humans and animal models of temporal lobe epilepsy (TLE), the redox regulated TCA cycle enzymes aconitase and -ketoglutarate dehydrogenase have been shown to be inactivated following status epilepticus (SE) in rats (Malinska et al., 2010)

That delay doesn't reduce efficacy, but it shifts when patients feel their ADHD medication 'kick in,' often causing them to mistakenly increase their stimulant dose

It has demonstrated low skin irritability when applied topically, both with and without microneedle-assisted delivery

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