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Taken together, these observations point to a future therapeutic paradigm that is inherently combinatorial: mitigation of metabolic and inflammatory stressors, protection and regeneration of endogenous -cells, and, where necessary, -cell replacement, complemented by targeted modulation of the gut microbiota

This reduced activity, combined with a potentially slower metabolism that can occur with persistent nutrient deficiencies, could indirectly contribute to weight gain over time

For skin, this means improved structural integrity, better hydration, restored elasticity, and reversal of the dermal thinning that accelerates after 40

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