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However, in the pivotal Phase IIb trial, it failed to demonstrate statistically significant weight loss compared to placebo at the primary endpoint, leading the developer (Metabolic Pharmaceuticals Ltd.) to terminate the commercial program

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This causes a decrease in the phosphorylation and activation of the transcription factor Smad 2/3, which is required for the transcription of type I procollagen, a precursor of type I collagen, namely the COL3A1 and COL1A1 genes (1,55,57)

There was an observed association of dose on height velocity during the first year of treatment