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Some side effects that may be seen after injectable B12 are: mild diarrhea itching or rash nausea and vomit headache swelling venous thrombosis pulmonary edema or congestive heart failure allergic reaction or anaphylaxis (rare) Caution : Vitamin B12 in the form of cyanocobalamin (found in most dietary supplements) should be avoided by people with Lebers disease (hereditary optic neuropathy), as it can cause severe atrophy of the optic nerve (10)

The effect of dual hexa-histadine tags had on purification of the GST-GFP protein was not analyzed