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Glutathione is taken orally to treat cataracts and glaucoma, to prevent aging, to treat or prevent alcoholism, asthma, cancer, heart disease (atherosclerosis and high cholesterol), hepatitis, liver disease, diseases that weaken the body's defense system (such as AIDS and chronic fatigue syndrome), memory loss, Alzheimer's disease, osteoarthritis, and Parkinson's disease

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A 2024 randomised trial found IV glutathione reduced melanin by 18.7% over eight weeks, while oral glutathione at higher cumulative doses reduced melanin by only 3.2%

As an alarming finding, the activation of GLP-1R has been associated with developing thyroid cancer [64, 65]