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Abstract Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by bladder and/or pelvic pain, increased urinary urgency and frequency and nocturia

Vitamin B12 is naturally found in animal products such as meat, fish, poultry, eggs, and dairy products

Log-Rank (Mantel-Cox) test was employed to compare the difference in survival analysis

Recently, inhibitors targeting FA metabolism have been applied in preclinical studies [52], e.g., CD36 blockers are optionally combined with ICB therapy for melanoma and pancreatic cancer