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Insulin resistance as well as the hypertensive response can cause damage to the structural integrity and transport function of the bloodbrain barrier, increase the permeability of the bloodbrain barrier (24), and the entry of free fatty acids (FFA) and other plasma components into the brain tissue to disrupt the homeostatic balance of the brain, as well as the entry of immune cells and inflammatory factors in the peripheral circulation into the CNS, which can cause further neuronal damage, thus leading to cognitive dysfunction (19)

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Use of the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH for the manufacture of a medicament for use in the treatment by nasal administration of sexual dysfunction as multiple agent therapy with use of a PDE-5 inhibitor for the manufacture of a medicament for use in the treatment by oral administration of sexual dysfunction

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