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This mutation, along with changes in membrane fluidity and gene expressionsuch as the upregulation of genes related to surface proteins and phosphoglycan biosynthesis, and the downregulation of stress response and folate transport geneshighlights specific genetic and metabolic adaptations rather than a general resistance profile

The size distribution was between 50 and 90 nm in diameter

Preclinical Models of Cocaine and Psychostimulant Use Disorders Cocaine and related psychostimulants such as amphetamines exert their addictive potential primarily via enhanced dopaminergic signaling in mesolimbic circuits, particularly through increased dopamine availability in the NAc

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