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189 Management of DRPN focuses on optimizing glycemic control to prevent further nerve damage

Importantly, supplementation can **increase** measurable NAD+ metabolism: in a 2018 randomized, placebo-controlled crossover trial published in Nature Communications by Martens and colleagues at the University of Colorado Boulder (24 healthy middle-aged and older adults), 1,000 mg/day of the NAD+ precursor nicotinamide riboside (500 mg, twice daily) elevated NAD+ in blood cells by roughly 60% versus placebo over 6 weeks, with no serious adverse events reported

PT-141 Modern Peptides is Modern Research LLC, a Southern California research-products company founded in 2022

Use only sterile, single-use syringes and needles for both the addition of the diluent and the extraction of the reconstituted solution