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The allosteric modulation in glucagon-like peptide-1 receptor and glucagon receptor is characterized by extracellular loop 1 forming a short -helix structure adjacent to the extracellular tips of transmembrane helix 2 in glucagon-like peptide-1 receptor and transmembrane helix 3 in glucagon receptor [3]

Pregnant rabbits given subcutaneous doses of 0.01, 0.025 and 0.05 mg/kg/day liraglutide from gestation day 6 through day 18 inclusive, had estimated systemic exposures less than the exposure in obese humans at the MRHD of 3 mg/day at all doses, based on plasma AUC comparison

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