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Clinically, GLP-1-based therapies offer the additional advantage of established cardiovascular protection and renal benefits, making them particularly attractive for the large proportion of MASLD patients with comorbid cardiovascular disease or type 2 diabetes

It is therefore interesting to explore whether HOXA2 could regulate ER stress-mediated renal fibrosis via SIRT1 in CKD

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Increased Dosing Complexity More injections increase the possibility of: Dosing confusion Missed doses Improper measurements Medication errors Off-Label Use Most FDA-approved GLP-1 medications are designed for once-weekly administration