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A large randomized study in 720 patients with STEMI undergoing primary angioplasty compared four CIN prophylactic regimens: hydration with sodium chloride alone, and hydration with sodium chloride plus either NAC (oral), sodium bicarbonate (infusion), or NAC plus sodium bicarbonate [180]

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In the case of getting coverage for surgery or medication, you may need documentation from your doctor that youve already tried RICE therapy and that further treatment is medically necessary