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103,104 Besides, ME2 ablation results in elevated cellular ROS levels, which activates the AMPK pathway and then stimulates TP53 to attenuate melanoma cell proliferation

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Collectively, they make clear that low serum fT 3 and NTIS at admission strongly predict poor outcomes in these patients, although the utility of measuring fT 3 at admission is still disputable in terms of cost-effectiveness since other biochemical indicators provide similar predictive value

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