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EGCG-treated rat liver showed a decrease The MDA levels was significantly decrease, while GSH and SOD levels was clearly elevated in mice treated with EGCG (83), the antioxidant activity of the liver increased

They are formed through a process called keratinization, aka epidermal cell differentiation

Within hepatocytes, -3 PUFAs occupy a metabolic decision point, where they may be directed toward -oxidation for energy production or retained for structural incorporation and further elongation and desaturation (62)