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For instance, the transduction efficiency of human macrophages mediated by lentiviral vectors is extremely low, and this barrier directly hinders the transformation of gene therapy based on macrophage modification from rodents to clinical practice

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2 Discovery of sulforaphane and the NRF2-ARE pathway Sulforaphane is an isothiocyanate, derived from the precursor glucoraphanin (Fahey et al., 1997

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