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Diet The PEMT gene needs choline, and a diet without enough puts puts you at risk for fatty liver, muscle damage, and even liver cell death

FIGURE 5 3.6 Effect of DXN and TIR on antioxidant enzymes in the rat brain In the group treated with DXN, the relative expression levels of SOD and GPx were significantly reduced correlated to the control group, with p -values of less than 0.01 and 0.0001, respectively

Future research should deepen the understanding of ferroptosis in various OA subtypes, identify additional key regulatory factors and signaling pathways, and explore the interactions between ferroptosis and other cell death modalities, such as apoptosis and necrosis