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Fetoui H, Makni M, Garoui EM, Zeghal N

Event Phase 2 Rate (12 mg group) Phase 2 Rate (Placebo) Nausea 45.8% 11.6% Diarrhea 33.3% 9.3% Vomiting 22.2% 2.3% Constipation 16.7% 7.0% Decreased appetite 22.2% 2.3% The nausea incidence at the highest dose a nausea percentage of roughly 46% makes it the single most reported adverse event in retatrutide clinical trials 2026 data

Some in vitro studies have shown that certain bacteria, such as Klebsiella pneumoniae an opportunistic human pathogencan use allulose as a nutrient when it is present in urine