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10.1001/jama.2018.18269 Summary Keywords acarbose, dipeptidyl peptidase-4 inhibitors, glucose-lowering efficacy, network meta-analysis, randomized controlled trials, tolerability and safety issue, type 2 diabetes, weight-loss effect Citation Zhang F, Xu S, Tang L, Pan X and Tong N (2020) Acarbose With Comparable Glucose-Lowering but Superior Weight-Loss Efficacy to Dipeptidyl Peptidase-4 Inhibitors: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Nevertheless, large-scale clinical trials are needed to assess their clinical potential and risk balance in more detail

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While GLP-1 agonists address only one component of this dual deficit, tirzepatide's simultaneous targeting of both pathways represents a more physiologically complete intervention