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Current research trends in NOX inhibitors focus on creating compounds that are both highly effective and specific to individual isoforms, as shown in Figure 2 ( 5.4 The nuclear factor erythroid 2-related factor 2 (Nrf2) The Nrf2 pathway serves as a critical endogenous defense mechanism against OS in HTN, orchestrating the transcription of antioxidant and cytoprotective genes that counteract vascular dysfunction (Lal et al., 2024)