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Defining the independence of the liver circadian clock
Published work on intranasal peptide delivery (for insulin analogs, calcitonin, and oxytocin) demonstrates that bioavailability for this size class without enhancers is typically in the low single-digit percent range, though these data are from different peptides with different charge profiles
Dihexa was derived from angiotensin IV with modifications to improve stability, potency, and oral bioavailability
A 2024 systematic review found some positive results (66.7% of studies reported positive impact), but methodological issues in those studies (small sample sizes, lack of biochemical validation, poor randomization) make it hard to draw firm conclusions
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