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Salamanca-Fernndez, E

The phase 1 clinical trials evaluated escalating doses of CB-839 in patients with advanced solid tumors among the patients with triple-negative breast cancer, RCC, mesothelioma, NSCLC, fumarate hydratase (FH)-deficient tumors, succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GIST) or non-GIST tumors, cMyc-mutated tumors, and isocitrate dehydrogenase-1 (IDH1)- or IDH2-mutant tumors in combination with standard of care chemotherapy

IGF-1 is essential for muscle regeneration and hypertrophy

Scientific interest centers on how the peptide interacts with cellular signaling pathways that researchers commonly examine when modeling tissue maintenance and recovery in experimental systems