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Thus, during short-term fasting, changes in free and bioactive IGF-I rather than total IGF-I appear to be at least in part responsible for the increased GH secretion (111, 112), intermittent fasting (113), nor long-term calorie restriction (114) exerts any consistent inhibitory impact on serum IGF-I levels

Am J Pathol 180:221234 Janssen A, Fiebiger S, Bros H, Hertwig L, Romero-Suarez S, Hamann I, Chanvillard C, Bellmann-Strobl J, Paul F, Millward JM (2015) Treatment of chronic experimental autoimmune encephalomyelitis with epigallocatechin-3-gallate and glatiramer acetate alters expression of heme-oxygenase-1

Scharf, D

It does this partly by upregulating the genes responsible for extracellular matrix proteins and partly by increasing the production of glycosaminoglycans (GAGs) the ground substance that supports the collagen network [1]