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10.1038/s41380-019-0423-3 69

Since severe hypoxia also goes hand in hand with lack of nutrients, AMPK, which is one of the main regulators of metabolic stress, is often activated under hypoxia and can regulate autophagy directly by phosphorylation of ULK1 as well as indirectly by inactivation of mTOR (266)

Over time, plaques can narrow arteries or rupture, causing thrombosis and acute myocardial infarction ( Natural products used in TCM have shown significant anti-atherosclerotic activities in preclinical studies by simultaneously counteracting the aforementioned pathogenic mechanisms (Si and Lai, 2024)