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Distribution and Function of GLP1R GLP-1R is widely distributed across many tissues and organs, including the pancreas, stomach, duodenum, lungs, heart, kidneys, and brain

Therefore, while the historical success of GLP-1 agonists suggests a higher PoS, each new drug candidate must be evaluated on its own merits

Other preferred nucleic acid molecules comprise sequences that encode IgG forms of the antibodies of the invention or murine chimeric forms, for example those as described in Example 6

107,108 Although the pancreatic beta-cells are the well-characterised target for GLP-1, the incretin hormone also targets multiple other organs