Collectively, these findings demonstrate that Enz induces copper-dependent cell death in PCa cells via mitochondrial disruption, copper accumulation, and DLAT aggregation
Biochem Biophys Res Commun 279:324329 Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG (2004) Genetically altered mice to evaluate glutathione homeostasis in health and disease
ROS are mainly produced in the mitochondria during oxidative phosphorylation, but they are also generated in the endoplasmic reticulum (ER) when disulfide bridges are formed during oxidative protein folding, especially in cell types with a high protein production load like hepatocytes or pancreatic cells
The bridge from genes changed to cell function changed is still half-built, and most of the published work leans on dermal fibroblasts, with far less on the cardiac, lung, or joint varieties, which makes generalizing across tissue types shakier than it sounds