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Arrows indicate when the investigational product was administrated: at day 1, 29, and 57

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Functional changes in the microbiota of low-gene-count patients primarily consist of a decrease in butyrate-producing bacteria and an increase in the ratio of Akkermansia to Ruminococcus gnavus , which lead to decreased methane production potential, decreased hydrogen production potential, enhanced mucus degradation, and increased peroxidase activity (le Chatelier et al., 2013)