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Celecoxib is an approved COX-2 inhibitor that was initially used to treat osteoarthritis and rheumatoid arthritis due to its anti-inflammatory and analgesic effects [102]

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GLP-1RAs can reduce the IL-6/STAT3 signaling pathway and enhance the cytotoxicity of NK and CD8 + T cells, potentially promoting the elimination of cancer cells (Lu et al., 2021

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