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FcRn is broadly expressed across a range of hematopoietic and non-hematopoietic cells 37,38,39,40 , including endothelial cells, where it is predominantly localized within intracellular endosomal compartments 41,42,43,44,45,46,47,48,49

Age combined with foot mechanics such as high arches or flat feet as well as abnormal gait patterns together with obesity inappropriate footwear choices and genetic predispositions all contribute to developing this painful condition

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