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These symptoms typically occur during dose escalation and often improve with continued therapy

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As UT Southwesterns Chief and Professor of Obstetrics and Gynecology, Catherine Spong, M.D., noted in Vox, that excluding pregnant patients from GLP-1 RA research over safety concerns is to provide care without adequate evidence. A 2023 observational study involving 50,000 pregnant women with Type 2 diabetes found no statistically significant differences in the number of major congenital malformations among the more than 900 women who were taking GLP-1 RAs when they learned they were pregnant

However, some patients respond well at lower doses