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The aim of the current exploratory analyses was to investigate whether different combinations of background medications and insulin regimens affected the efficacy and safety of oral semaglutide compared with active comparators and placebo in the PIONEER 3, 4, 5, 7 and 8 trials

2.4.1.1 Effects of ISL on hepatic oxidative stress ISL pretreatment prevented from triptolide-induced hepatotoxicity by inhibiting MDA and restoring the levels of glutathione, glutathione peroxidase (GPX), SOD and catalase (CAT) via activation of the Nrf2 pathway in an acute liver injury model (Cao et al., 2016)

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On the other hand, the characteristic of immune checkpoint inhibitor such as anti-PD-1 tends to be durable, with lower response rate