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The clinical benefit was evaluated by comparing parameters qualifying the response to treatment (change from baseline UPDRS motor score) estimated for SC and SL administration over the interval 0 to 90 min post-dose using trial simulations

Human evidence and its limits Controlled human feeding studies show increases in TMA or TMAO after high intake of L-carnitine or choline in many subjects

Additionally, 2.9% of participants were forced to withdraw to serious side effects

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